1. How to determine the re-test or expiry dates.

2.  Acceptable % uncertainty in purity?

How are you using open-access LC-MS instrumentation to support drug development?  Is this instrumentation being used by both process chemists/engineers as well as by analytical chemist?  What issues have you experienced?

How are you using higher-pressure (>400bar) LC instrumentation to support drug development?  Is it being used only for method development, but not for routine use?  How will this instrumentation be used in your QC labs?

One of the new events at Pittcon 2007 was the Conferee Networking Sessions which introduced the Pittcon community to an interactive forum for discussions of issues surrounding specific topics. One of the sessions was “Use of LC/MS and New LC Technologies to Improve Efficiency in Pharmaceutical Development” moderated by Bryan Castle and Todd Gillespie of Eli Lilly & Company. The session was well attended and the discussions raised many questions about methods to improve efficiency and reporting of data, quality vs quantity sample analysis, old and new technologies, etc. Because participants wanted to continue the discussion, we have introduced this Pittcon open forum website to encourage you to post your questions and comments regarding specific areas of LC/MS and pharmaceutical development that the Analytical and Pittcon communities can answer or discuss further.